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Sep 02 2014

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    Three Peptides, Three Mechanisms
    At a Glance Comparison Table
    Feature Semaglutide Tirzepatide Retatrutide
    Receptor targets GLP-1 only GLP-1 + GIP GLP-1 + GIP + glucagon
    Number of agonists Single Dual (two) Triple (three)
    Half-life (animal models) ~7 days ~5 days ~6 days
    Molecular weight (Da) 4,113.6 4,813.4 ~4,900
    Amino acid length 31 39 ~40
    Peptide Sciences™ purity ≥99% ≥98.5% ≥98%
    Primary research use Selective GLP-1 studies Dual pathway
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    Fatty acid modification C18 at Lys26 C20 at Lys20 C18/C20 hybrid
    DPP-4 resistance Yes (Aib substitutions) Yes (Aib substitutions) Yes (Aib substitutions)
    SKU PS-SEMA-5mg PS-TIRZ-10mg PS-RETA-10mg
    The Incretin System: Background for Researchers
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    Hormone Receptor Primary Effects Secreted By
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